A Review of Systemic Retinoid Therapy for Acne. Part 3

Acne conglobata is certainly the best denotation for isotretinoin
therapy; however acne fulminans, after initial “calming” of the
exasperation with oral tapering dose steroids over 4-6 weeks, responds
well to the retinoid. Gram-negative folliculitis can be effectively
treated not only with ampicillin, co-trimoxozole or trimethoprim, but
with isotretinoin as well.

Hidradenitis suppurativa and rosacea patients have benefited from
isotretinoin therapy as well. Isotretinoin is used in pyoderma faciale
after initial oral steroids for the start 4 weeks.
It has not shown public presentation in vasculitic acne, which is
usually treated with oral steroids, azathioprine or cyclosporine. Acne
excoriee is often quelled with a education of isotretinoin.
Good results have been reported in its use for granulomatous perioral
dermatitis.ContraindicationsParabens allergy is a contraindication to
oral therapy with isotretinoin because parabens is an excipient in the
medicine.
Due to the “retinoid syndrome” of possibleness kinship defects,
pregnancy is an absolute contraindication.
With this in mind, the manufacturing business has developed the
Pregnancy Prevention Programâ„¢.
This promulgation educates the brute participant role about the need
for two effective methods of contraception and avoidance of pregnancy
during handling and for 1 calendar month after therapy
endpoint.Although the pregnancy rate has decreased to 0.003% in the US
according to the 2001 Slone Accutane® Epidemiology Database, the
absolute definite quantity of pregnancies has not decreased due to
increased amount of prescriptions.
Reasoning of the Slone data show that the affected role most likely to
have an Accutane® exposed pregancy is a 26 year old cleaning woman.
In dictation to savoir-faire these concerns, as of April 2002, in the
US, this system has evolved into the SMARTâ„¢ Announcement (System to
Manage Accutane Related Teratogenicity) developed by the manufacturing
business and the US FDA.

This is a part of article A Review of Systemic Retinoid Therapy for Acne. Part 3 Taken from "Generic Isotretinoin Accutane" Information Blog